Liverpool vs PSV

The game between Liverpool and PSV will take place at Anfield in Liverpool on Wednesday, 26 November 2025. Kickoff is scheduled for 20:00 GMT.

Liverpool head into the fixture down a number of players. Right-backs Conor Bradley and Jeremie Frimpong are unavailable, as is long-term absentee Giovanni Leoni. There is also no Florian Wirtz through muscular problems. As a consequence the side may see Dominik Szoboszlai shift into a makeshift right-back role. Up front, Mohamed Salah should start alongside Cody Gakpo and Hugo Ekitike, with Ekitike likely preferred over a struggling Alexander Isak. On PSV’s side the injury list is shorter — only Alassane Pléa and Ruben van Bommel are missing — and Guus Til is expected to lead the attack as a makeshift striker.

Tactically, Liverpool under their coach Arne Slot are likely to line up in a 4-3-3 (or modified 4-2-3-1) shape, aiming to dominate possession, move the ball quickly through midfield and exploit the flanks, but also having to cover for defensive absences on the right. PSV under Peter Bosz should respond with a 4-2-3-1 system focused on quick transitions, vertical passing, and exploiting any gaps — especially with midfielders like Joey Veerman and Ismael Saibari providing energy and support, and Til as focal point up front.

Press and media commentary ahead of kickoff have stressed how much this match matters for Liverpool’s European ambitions amid a terrible domestic run — recent league defeats have raised serious question marks over confidence and defensive solidity, so many view this game as a chance for redemption. Meanwhile PSV are regarded as dangerous underdogs: their recent run of form, strong domestic position and attacking confidence make them capable of punishing any Liverpool mistake.

Analysts in studio previews highlight a likely open, high-tempo and possibly high-scoring affair. Many expect both teams to find the net, pointing out that while Liverpool still have attacking depth and home advantage, their defensive frailties and makeshift back-line could prove vulnerable. A narrow home win is often seen as the likeliest outcome — but only if Liverpool start assertively and avoid defensive lapses.