A major Europa League clash is on the horizon as Real Betis prepare to face Lyon on Thursday, 6 November 2025, at the Estadio de La Cartuja in Seville, with kickoff set for 20:00 local time. The match is shaping up to be a key moment in the group stage, with both teams chasing qualification to the knockout rounds.
Real Betis will be missing key midfielder Isco due to injury, while defender Junior Firpo is unavailable because of a hamstring issue. Ricardo Rodríguez remains a doubt after leaving the previous La Liga match with muscle discomfort. Lyon, meanwhile, are dealing with the absence of Orel Mangala and Ernest Nuamah, both recovering from knee injuries. Malick Fofana is out with an ankle problem, and Tanner Tessmann is a doubt after suffering a knock in the last fixture.
Manuel Pellegrini is expected to keep Betis in their usual 4-2-3-1 system, emphasizing width and fluid attacking play through Antony and Rodrigo Riquelme, combined with a controlled press in midfield. Paulo Fonseca’s Lyon will likely mirror that formation but adopt a more compact, defensive style, aiming to hit on quick transitions and use the pace of their wingers to threaten on the counter. Both coaches are preparing for a tactical duel, aware that small adjustments could determine the outcome.
In the Spanish and French media, coverage has focused on contrasting form. Betis are unbeaten at home in recent months but have drawn two of their three group games, while Lyon boast a perfect record so far, with three wins and no goals conceded. Journalists note that Betis will need to start with intensity and avoid early defensive lapses against a Lyon side that thrives on controlling rhythm once ahead.
Pre-match studio discussions have centered around whether Betis’ wide play can break down Lyon’s rigid defensive structure and how Lyon’s midfield pairing will cope under sustained pressure in Seville. Analysts predict a tight, tactical battle, where a set-piece or counterattack could swing the balance. The general sentiment is that the team showing greater composure and patience will have the best chance to claim three points.
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Watch and Download Real Betis vs Lyon full match replay and highlights, At Thursday, November 06, 2025. The match played at Estadio La Cartuja de Sevilla, in Europa League, UEFA.
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